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Wales have already qualified for the World Cup quarter-finals however they will aim to acquire all of their pool matches for the first time since 1987 when they confront Uruguay.
The side of warren Gatland need two points to finish top of Pool D.
And although Uruguay stunned in the championship, Wales will expect to triumph.
With just four days to recover from Wednesdays bruising win over Fiji, Gatland has made 13 changes to his group.
Centre Hadleigh Parkes and wing Josh Adams retain their places but, as Gatland mentioned they would have been rested had Wales not sustained so many harms against the imposing Fijians.
Center Jonathan Davies and fly-half Dan Biggar were driven off the field , while Adams suffered a leg and fellow wing George North hurt his ankle.
So with several more in need of a rest and a couple of players injured, Sunday Gatland is aiming to safeguard as much as he can before a against France per week.
This means first World Cup appearances for Bradley Davies and next tsp Adam Beard, hooker Ryan Elias, scrum-half Aled Davies and wing Hallam Amos.
Lots of the players that started over Georgia, Australia and Fiji would aspire to recover their positions – however Gatland has cautioned there isnt any foregone conclusion.
Its a tiny juggling act with all the four-day turnaround, he explained.
We knew from the start we were going to expose a few players. entering this match with just one 10 15, we spoke before the World Cup.
So weve been looking at pay there. It has been hard.
Weve got a fresh forward package and they are enthusiastic and looking forward to the opportunity.
The message to the gamers from Uruguay is that the door is not shut.
There are chances for players to head out there and impress and stake a claim for a quarter-final spot.
Uruguay, meanwhile, will be bid to win two matches in a World Cup campaign for the first time.
One pool match has been won by them on two occasions – in 1999 and 2003 – however the victory over Fiji has granted them the chance to create history.
Los Teros have lost all eight of the World Cup fixtures against Tier 1 sides, by an average of 54 points.
And although they were hammered 54-9 from Wales their win against Fiji was evidence of the own improvement.
Captain Juan Manuel Gaminara spoke passionately about his groups progress immediately after that victory, and he wants Uruguay to be given opportunities to test themselves against teams such as Wales.
We do not think we should have to wait every four decades to perform Tier One groups, he said.
We ought to play with them every year.
Wales: Halfpenny; Adams, Watkin, Parkes, Amos; Patchell, A Davies; Smith, Elias, Lewis, B Davies, Beard, Shingler, Tipuric (capt), Wainwright.
Replacements: Dee, Carre Ball, Moriarty, James Davies, T Williams, G Davies.
Uruguay: Mieres; Leivas, Cat, Vilaseca, Freitas; Berchesi, Arata; Sanguinetti, Kessler, Arbelo, Dotti, Leindeker, Gaminara (capt), Civetta, Nieto.
Replacements: Pujadas Rombys, Magno, Diana Inciarte, Silva.
Officials: Referee, Angus Gardner (Australia); Assistant referees, Luke Pearce (England), Karl Dickson (England); TMO, Rowan Kitt (England).
Wales head coach Warren Gatland:Weve got to make sure we do a job early against Uruguay. That is what World Trainers are about although it is challenging with such a turnaround.
We have talked about producing as much power in depth in the team as we can within the last three or four years.
The group is in a good place emotionally. You will find a group of players that are enthusiastic about the opportunity get their game in a World Cup to head out and, for a great deal of these.
Were expecting another difficult match but also a fantastic performance from our side.
Uruguay captain Juan Manuel Gaminara:weve been visualising winning two games at the World Cup because, when we dowe qualify for France 2023 automatically.
Were getting much better as the tournament continues. We usually only play three to four times a year. Were getting accustomed to that many games in a brief time period.
We have to disrupt Waless kicking game. We notice that their number 9 usually kicks a whole lot and so we have to worry that kick.
This will be the second of two World Cup games to be performed in Kumamoto Stadium, a 32,000-seat arena constructed in 1998.
France beat Tonga in another match at the floor, which will be similar in design to Munsters Thomond Park and Hong Kong Stadium.
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